• br Transparency document br The authors have

  2020-07-31

  

  Transparency document The authors have noted that there was a mix-up in the picture for CK1δwt in Fig. 2. The original picture is now presented in the corrected figure. Furthermore, to clearly indicate which CK1δ mutant has been used CK1δmt is now named CK1δmt(Rev). Introduction Casein kina

• retinoid x receptor Our experiments show that the N terminal

  2020-07-30

  

  Our experiments show that the N-terminal ubiquitination results in an overall slowing down of Ube2Es toward the E3/substrate rather than affecting their chain-building capacity. The fact that Ube2E1wt activity is not restricted toward mono-ubiquitination is also evident from Fig. 4a, where the full-

• The SEC in cfALDH is predicted to have a

  2020-07-30

  

  The SEC in cfALDH is predicted to have a volume between that seen in the sheep ALDH1A1 (Volume 670.2 Å3) and the human ALDH2 (Volume 558.07 Å3) with a calculated volume of 635.05 Å3 when the sheep ALDH1A1 1BXS is used as the template (Fig. 4b). The GQCC motif is at the bottom of the SEC in cfALDH as

• br Acknowledgements br The Nudix protein superfamily

  2020-07-30

  

  Acknowledgements The Nudix protein superfamily is vast and diverse , . It comprises 29,400 members in the Pfam database (version 26.0) (), of which less than 1% have been experimentally characterized. Enzymes from this family have been shown to catalyze a large variety of seemingly distantly r

• Kuo et al Have shown that DAPK

  2020-07-30

  

  Kuo et al. (2006) Have shown that DAPK1 function in inhibiting microtubule (MT) assembly is through the activation of microtubule affinity-regulating kinases (MARK)/PAR-1 family kinases MARK1/2, which destabilize MT by phosphorylating tau and related MAP2/4. This relation with DAPK1 has demonstrated

• Asthma pathogenesis involves not only acute airway obstructi

  2020-07-30

  

  Asthma pathogenesis involves not only acute airway obstruction, but also chronic eosinophilic airway inflammation including airway hyperresponsiveness. It is unclear whether antagonism of CysLT2 receptors would results in anti-inflammation in Bax inhibitor peptide V5 patients. Further studies of th

• br Materials and Methods br Results br Discussion We first

  2020-07-30

  

  Materials and Methods Results Discussion We first confirmed that translational repression of target mRNAs by vigilin (Figure 1). It is known that vigilin binds a large number of mRNAs (estimated 700 mRNAs; [12]). We demonstrate that vigilin directly interacts with the pyrimidine-rich elemen

• Our results signify that both membrane anchored

  2020-07-29

  

  Our results signify that both membrane-anchored and soluble isoforms of DDR ECD 78 4 may be important in ECM remodeling. In this regard, several soluble collagen-binding proteins secreted in the ECM—decorin,3, 32, 33, 34 lumincan,3, 34, 35 biglycan,34, 36 fibromodulin,34, 35, 36 periostin, aggrecan

• In various thermal recovery processes

  2020-07-29

  

  In various thermal recovery processes of heavy SCR 7 and bitumens, e.g., Steam Assisted Gravity Drainage (SAGD) and Cyclic Steam Stimulation (CSS), hydrocarbons are produced by heating reservoir formations with a hot heat-carrying fluid such as water. Increasing temperature reduces the oil phase vi

• The current research examines whether AP engagement and succ

  2020-07-29

  

  The current research examines whether AP engagement and success is associated with CPA exam performance. It also more narrowly identifies specific types of AP courses that are likely to be associated with higher CPA exam performance. Using constructs from Bloom\'s Taxonomy of Learning (Bloom & Krath

• br The LSCP model and its properties In

  2020-07-29

  

  The LSCP model and its properties In this section, we first introduce the LSCP model in Section 2.1. Some examples of the model are presented in Section 2.2 and basic properties of the model are presented in Section 2.3. Finally, Section 2.4 introduces finite dimensional approximations necessary

• Endoplasmic reticulum ER functions that respond to cellular

  2020-07-29

  

  Endoplasmic reticulum (ER) functions that respond to cellular perturbations are critical to the survival of cells. Unfolded and misfolded proteins accumulate in the ER lumen under a number of cellular stress conditions, including nutrient deprivation, oxidative stress, hypoxia, glycosylation altera

• DGK metabolizes DG which enhances PKC activity DGK regulates

  2020-07-28

  

  DGK metabolizes DG, which enhances PKC activity [10,11]. DGKδ regulates the EGFR pathway for the epithelial cell differentiation of lungs and skin [27] and controls insulin receptor signaling for glucose uptake in skeletal muscle [20] by attenuating cnPKC activities. In this study, we found that the

• It is well known that A peptide is

  2020-07-28

  

  It is well known that Aβ peptide is a neurotoxin and it is broadly used to mimic Alzherheimer’s disease (AD), condition to explore the mechanisms behind neuronal death in such diseases. In an in vitro study, Cheung et al. (2011) showed that the exposure of cultured neurons to Aβ results in cell deat

• Another in vitro system uses the enzyme phospholipase

  2020-07-28

  

  Another in vitro system uses the enzyme phospholipase A2, which is inactivated as the result of fusion to the C-terminus of LC3B adjacent to the cleavage site (Ketteler and Seed, 2008, Shu et al., 2010). When the fusion protein is cleaved by Atg4B, PLA2 is released to regain its activity, which can

15256 records 777/1018 page Previous Next First page 上5页 776777778779780 下5页 Last page