• When we compared the effects in FST induced by GAL

  2021-09-15

  

  When we compared the effects in FST induced by GAL and GAL(1–15), we observed that the increase in the immobility induced by GAL(1–15) was significantly higher than the one induced by GAL (Millon et al., 2015). Moreover, in climbing behaviour, GAL(1–15) also induced a stronger decrease in climbing r

• Introduction G quadruplexes are therapeutically important no

  2021-09-15

  

  Introduction G-quadruplexes are therapeutically important non-canonical nucleic Medroxyprogesterone acetate structures that are formed by a planar assembly of four guanines, termed G-tetrads (Fig. 1), in the guanine rich regions of genome [[1], [2], [3]]. As it is getting increasingly established,

• With the aim to identify potential novel targets in

  2021-09-15

  

  With the aim to identify potential novel targets in CVD, we applied proteome analyses on vascular tissue of these frequently used mouse models of atherosclerotic disease in the presence and/or absence of diabetes. Potential targets for intervention identified with this approach were validated in hum

• (-)-Bicuculline methiodide Introduction Histamine Imidazolyl

  2021-09-15

  

  Introduction Histamine [2-(4-Imidazolyl)-ethylamine] is an important mediator of many physiological and pathological processes including inflammation, gastric (-)-Bicuculline methiodide secretion, neuromodulation, regulation of immune function, cell proliferation and differentiation, among others.

• Long non coding RNAs lncRNAs are a

  2021-09-15

  

  Long non-coding RNAs (lncRNAs) are a class of RNA transcripts which are over 200 nucleotides in length and not translated into proteins (Ponting et al., 2009). Recent studies showed that lncRNAs have been identified as crucial regulators of gene expression, chromatin remodeling, and cell cycle (Wahl

• While phosphorylation site motifs are

  2021-09-15

  

  While MG0103 site motifs are typically described in terms of residues that promote phosphorylation, negatively selected residues can also be an important component of substrate recognition. Such ‘forbidden’ resides can act as a filter to prevent phosphorylation of a site by the ‘wrong’ kinase, which

• The frequency of GSTM and GSTT

  2021-09-15

  

  The frequency of GSTM1 and GSTT1 null genotypes vary in different populations. For example, Hiragi et al. (2007) reported a frequency of 17–35% for the GSTM1 null genotype and 22–44% for the GSTT1 null genotype in Brazilians of African descent (Hiragi et al., 2007). Chen, Liu, and Relling (1996) rep

• br Acknowledgments This research was partially supported by

  2021-09-15

  

  Acknowledgments This research was partially supported by the National Key Research and Development Program of China (2018YFD1000800); the National Natural Science Foundation of China (No. 31872943; No. 31501779 and No. 31372059>); 12th Five-Year State Science and Technology Support Program (2014B

• br Materials and methods br Results br Discussion Although t

  2021-09-15

  

  Materials and methods Results Discussion Although there is general agreement that GPR109A has anti-lipolytic activity and that the NEFA reduction in response to nicotinic Ozagrel is mediated by GPR109A, whether GPR109A activation has any impact on plasma TG levels is unclear. Since the phe

• br AUTHOR CONTRIBUTIONS br ACKNOWLEDGMENTS br

  2021-09-14

  

  AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS Introduction Chronic neuropathic pain is a common symptom in patients with human immunodeficiency virus (HIV)-1 infection. Glycoprotein 120 (gp120) is an HIV-1 protein that can cause pain behaviors in animal models (Hao, 2013, Nasirinezhad et al., 2015,

• equol DNA repair is essential for cell survival and for tiss

  2021-09-14

  

  DNA repair is essential for cell survival and for tissue homeostasis given that cellular DNA is constantly challenged by various endogenous and exogenous genotoxic factors that generate DNA damage: structural and chemical modifications of a primary DNA sequence. Various organisms have evolved multip

• By regulation of synaptic glutamate concentration glutamate

  2021-09-14

  

  By regulation of synaptic glutamate concentration, glutamate transporters play an important role in limiting glutamate signaling and controlling the activation of glutamate receptors (Rimmele and Rosenberg, 2016). Reduced glutamate transport is thought to underlie the pathogenesis of numerous neurol

• br Discussion According to the generally accepted notion

  2021-09-14

  

  Discussion According to the generally accepted notion which originated from the study of ATP-depleted calculate the concentration the changes in Ca2+ homeostasis induced by ATP depletion and leading to the activation of the Gárdos effect are due to the inhibition of Ca2+ pumping, and the subseque

• Communication through GJ channels is regulated at different

  2021-09-14

  

  Communication through GJ channels is regulated at different levels and includes GJ plaque internalization into a single cell. Those vesicles contain the membrane of both cells and th assembled Cx43. The C-terminal domain of Cx43 interacts with different peptides and proteins. However, the internaliz

• How changes in APP processing by secretase lead

  2021-09-14

  

  How changes in APP processing by γ-secretase lead to AD is still not well understood. Deposition of amyloid beta (Aβ) peptide fragments of the amyloid precursor protein (APP) in amyloid plaques and hyperphosphorylated tau in neurofibrillary tangles are the cellular hallmarks of AD (O’Brien and Wong,

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