• To understand the impact of alterations in brain zinc

  2022-01-06

  

  To understand the impact of alterations in neuronal nitric oxide synthase zinc homeostasis, the role of Zn2+ as a neurotransmitter has to be appreciated. Certain regions of the brain including the neocortex and hippocampus harbour so-called “zincergic” (or “gluzinergic”) neurons, where Zn2+ is co-re

• Macroautophagy hereafter referred to as autophagy depends on

  2022-01-06

  

  Macroautophagy (hereafter referred to as autophagy) depends on an intracellular lysosome-dependent degradation system that maintains cellular metabolism and homeostasis [11]. Genes involved in these processes are termed autophagy-related genes (ATGs), which regulate autophagosome formation and compl

• In the course of an internal FAAH program

  2022-01-06

  

  In the course of an internal FAAH, program,, , , , , , , , , , , , , many very similar compounds were profiled in vivo with particular interest paid to their ability to penetrate the BBB. The compounds profiled were heteroaryl piperazinyl and piperadinyl ureas; a class of compounds, reported on pr

• Myocardial growth and maturation is regulated

  2022-01-06

  

  Myocardial growth and maturation is regulated in part by signals from the underlying endocardium (Brutsaert, 2003, de la Pompa and Epstein, 2012, Rentschler et al., 2010). More generally, endothelial CGP 41251 play an increasingly appreciated role in instructing organogenesis by providing inductive

• The number of small molecule GSK inhibitors is continuously

  2022-01-05

  

  The number of small molecule GSK-3 inhibitors is continuously rising and many have been tested in animals. These studies have provided additional support for specific roles of GSK-3 in neuronal functions under both normal and pathological conditions. Inhibition of GSK-3 has profound effect on neurop

• Amoxapine br Mutagenesis and Receptor Modeling Studies

  2022-01-05

  

  Mutagenesis and Receptor-Modeling Studies Signal Transduction and Receptor Desensitization Therapeutic Potential of HCA Receptor Ligands Although all members of the HCA receptor family are potentially interesting drug targets, only HCA2 is currently exploited as such. Therefore, this sectio

• While a role for YAP TAZ signaling in oligodendrocytes

  2022-01-05

  

  While a role for YAP/TAZ signaling in oligodendrocytes has not been described, these 2'-O-Methyl-ATP are also responsive to mechanical stimuli. OPC proliferation and migration can be altered by plating on substrates of varying stiffness [20], resulting in differentiation in a density-dependent manne

• The typical pharmacophore for GPR agonists contains

  2022-01-05

  

  The typical pharmacophore for GPR40 agonists contains four parts: head (acid moiety), central (phenyl ring), linker and tail (aromatic carbocyclic or heterocyclic ring) [20]. On the other hand, the chemical features that are required for the PPARγ agonists include hydrogen bond donors and acceptors

• Nuclear export of GK has been reported to

  2022-01-05

  

  Nuclear export of GK has been reported to be dependent on a GK nuclear export signal (NES), mapped to residues 300–310 (Shiota et al., 1999). The assignment of a nuclear export signal common to both the liver and pancreatic GK isoform sequence suggests a possible reversible translocation of GK acros

• AKR D is very highly expressed in human

  2022-01-05

  

  AKR1D1 is very highly expressed in human liver and based upon the observations outlined above, with respect to other steroid hormone pre-receptor metabolising enzymes, it is entirely plausible that AKR1D1 could represent a critical regulatory step in the control of metabolic phenotype within the liv

• The membrane metalloendopeptidase MME gene is located

  2022-01-05

  

  The membrane metalloendopeptidase (MME) gene is located at human chromosome 3q21-27. It encodes a 100-kD type II transmembrane glycoprotein, a widely expressed membrane metalloendopeptidase that degrades a number of substrates. The active site of the enzyme faces the extracellular space. MME is wide

• Several observations about structure activity relationships

  2022-01-05

  

  Several observations about structure–activity relationships can be made from this series, including that: (1) all lead compounds are NSAIDs of the 2-arylpropionic Cy5 NHS ester (non-sulfonated) class, (2) analogues with -oriented aryl substituents showed the best inhibition of FAAH, and (3) replacin

• The EZH overexpression group exhibited

  2022-01-05

  

  The EZH2 overexpression group exhibited upregulated CEP55 expression but downregulated methylation, suggesting that changes in EZH2 expression in lung adenocarcinoma result in differences of CEP55 methylation and expression. Moreover, according to TCGA database and GSE27262 chip data, CEP55 expressi

• It has been well established that triazophos is a

  2022-01-04

  

  It has been well established that triazophos is a classic resurgence-inducing insecticide favoring N. lugens population growth by fecundity stimulation, with enhanced contents of soluble sugar, crude fat, soluble protein content of fat body and ovary, glucose and trehalase activity but reduced treha

• Our investigation also showed NAC

  2022-01-04

  

  Our investigation also showed NAC increased the level of DAF and might protect HUVECs from complement activation. NAC, an antioxidant/mucous modifier, has displayed benefits in chronic obstructive pulmonary disease. Martinez de Lizarrondo et al [38] provided evidence that the molecular target underl

15208 records 489/1014 page Previous Next First page 上5页 486487488489490 下5页 Last page