• While the dogma of the mainstream considers Hippo pathway

  2022-04-09

  

  While the dogma of the mainstream considers Hippo pathway as a series of size-controlling kinases, there were still some controversial data supporting that YAP, a vital oncoprotein of Hippo downstream, is antagonistic to regenerative proliferation [[20], [21], [22]]. Known for its expansion-driving

• Glycogen synthase kinase GSK a serine threonine kinase has b

  2022-04-08

  

  Glycogen synthase kinase-3 (GSK-3), a serine/threonine kinase, has been confirmed to be involved in some biological processes in NaCl or wound-treated plants (Chen et al., 2003, Hai et al., 2001, Jonak et al., 2000). NO has been recently recognized as a vital signaling compound in plants. The NO don

• br Conclusions Beta cell specific expression in human

  2022-04-08

  

  Conclusions Beta cell-specific expression in human islets of DGCR2, GBF1, GPR44 and SerpinB10 has not previously been described, although the proteins have partly been characterized in other contexts not related to beta Leupeptin or diabetes. DGCR2, GPR44 and SerpinB10 were negative in all other

• Conjugated BAs via S PR

  2022-04-08

  

  Conjugated BAs via S1PR2 also activate ERK1/2- and AKT-signaling pathways leading to the growth and invasion of cholangiocarcinoma cells. The role of conjugated BAs via S1PR2 to regulate apoptosis or cancer progression remains to be dissected. Nevertheless, there is no doubt that the composition of

• br A selective inhibitor of mammalian histone deacetylase tr

  2022-04-08

  

  A selective inhibitor of mammalian histone deacetylase, trichostatin A, reduces GnRH mRNA expression Epigenetic mechanisms controlling GnRH expression have been reported, and these mechanisms may be involved in the development and maturation of GnRH neurons in the brain (Gan et al., 2012, Kurian

• Several studies have shown that the levels of reactive

  2022-04-08

  

  Several studies have shown that the levels of reactive dicarbonyls are higher in patients with diabetes as a result of hyperglycemia.49, 50, 51 Consequently, reactive dicarbonyl-derived AGEs are elevated in plasma and accumulate in tissues prone to secondary complications, including the lens, retina

• Morin is a flavonoid that has shown to

  2022-04-08

  

  Morin is a flavonoid that has shown to have effective anti-inflammatory and anti-tumor function [118]. Morin was able to block the activation of NF-κB pathway by ROS and inflammatory cytokines, preventing a signaling cascade resulting in cell death [121]. Morin exerted its control over the signaling

• br NLS and NES Mapping br Sequence Comparison

  2022-04-08

  

  NLS and NES Mapping Sequence Comparison of Gli NLSs—NLSs in ZF Domains Alignment of the Gli NLSs of representative metazoan animals suggests that the amino Natural Product Library residues in the ZF domains are strongly conserved (Figure 4.2, Figure 4.3B). However, the length of the interveni

• We speculated modulation of redox balance

  2022-04-08

  

  We speculated modulation of redox balance in brain, by activation of GIP receptor pathway. QA is known to mediate production of ROS, lipid peroxidation by its interactions with Fe2+ and formation of QA-Fe2+ complex (Braidy et al., 2010, Rios and Santamaria, 1991, Stipek et al., 1997). QA induces NOS

• br Presenilins and apoptosis Apoptosis also

  2022-04-07

  

  Presenilins and apoptosis Apoptosis, also known as programmed cell death, has a critically important role in tissue homeostasis, development, normal ageing and the pathogenesis of several diseases, including cancer and neurological disorders. The presenilins were first linked to apoptosis when ce

• In general the FDP gene is involved in isoprenoid biosynthes

  2022-04-07

  

  In general the FDP gene is involved in isoprenoid biosynthesis for normal growth and development of plant species while it is specifically involved in rubber biosynthesis (cis-1,4-polyisoprene units) in Hevea plant. When the HbFDP gene was over-expressed under the control of constitutive promoter in

• JMJD C is another JmjC domain protein discovered

  2022-04-07

  

  JMJD1C is another JmjC domain protein discovered as a putative oncogene in shRNA screens in MLL-AF9-, HOXA9-, and AML1-ETO-driven AML 40, 41, 42. Depletion of JMJD1C decreased the frequency of LICs by inducing their differentiation and impaired the growth and establishment of leukemia in serial tran

• In this current study we

  2022-04-07

  

  In this current study, we not only demonstrated the growth-inhibitory effects of the 2nd generation analog SL-1-39 on the HER2+ breast cancer cells, MDA-MB-453 and SKBR3 (Table 1), but we also demonstrated that the decrease in cell number was associated with an interruption of c-Myc tag progression

• The obtained sequence was deposited in

  2022-04-07

  

  The obtained sequence was deposited in GenBank under accession number MG703576; it showed a 99% identify with sample HE817764, reported as Demodex cornei, and with JF784000, reported as D. canis. Molecular and phylogenetic analyses and the morphological characteristics helped to rule out D. cornei.

• Interestingly in vivo infusion and uptake of Ang II

  2022-04-06

  

  Interestingly, in vivo infusion and uptake of Ang II in intact mice indicated that multiligand endocytic receptor megalin has at least some role in the uptake of Ang II and the downstream signaling process in proximal tubule GSK J4 free base (PTCs) in vivo [173]. Earlier in vivo studies showed that

15262 records 443/1018 page Previous Next First page 上5页 441442443444445 下5页 Last page