• Last we demonstrate that the role of EZH

  2022-07-06

  

  Last, we demonstrate that the role of EZH2 as a transcriptional activator, with AR being a key target, coexists with its conventional catalytic role in gene repression and plays important oncogenic functions in AR-driven PCa (Figure 7F). Enzymatic EZH2 inhibitors such as EPZ and GSK126, although eff

• Introduction Histone is the core component

  2022-07-06

  

  Introduction Histone is the core component of chromatin and histone modification is one of the key mechanisms of epigenetic regulation (Bannister and Kouzarides, 2011). Amino Diosmetin mg residues on histone tails can be modified under different mechanisms including acetylation, methylation, phosp

• Hippo pathway proteins could synergistically regulate germ c

  2022-07-06

  

  Hippo pathway proteins could synergistically regulate germ cell development with some specific receptors. Kassab et al. [27] found that epidermal growth factor (EGF) receptor was localized in testicular germ Myriocin receptor and played important roles in bovine spermatogenesis. Likewise, insulin-l

• HOs can be found in both plants and animals and

  2022-07-06

  

  HOs can be found in both plants and animals and they are evolutionarily conserved proteins [8]. There are two HO isoenzymes: inducible heme oxygenase-1 (HO-1) and constitutive heme oxygenase-2 (HO-2) encoded by different genes [9,10]. Biosynthesis of a stress-inducible HO-1 can be triggered by a var

• br Structural studies of GCAP Recoverin was the

  2022-07-06

  

  Structural studies of GCAP Recoverin was the first member of this subfamily of Ca2+-binding Apelin-13 synthesis to be investigated by structural methods [27], [54], [55], [56], [57], [58]. These proteins have four EF-hands arranged in pairs that give rise to amino- and carboxyl-terminal domains.

• GPR is a member of the G protein coupled

  2022-07-06

  

  GPR119 is a member of the G protein-coupled receptor family, and is highly expressed in pancreatic β-cells and intestinal endocrine cells. It has been proposed that GPR119 agonists modulate glucose homeostasis by indirectly stimulating glucose-dependent insulin release through enhancing pancreatic c

• There is sufficient evidence to indicate that kisspeptin

  2022-07-06

  

  There is sufficient evidence to indicate that kisspeptin plays a role in regulating sheep reproduction. However, the molecular mechanism by which kisspeptin regulates GnRH daminozide and reproduction has remained unclear. Therefore, in this study on GnRH in sheep, the promoter region of GnRH was cl

• br The presence of an active glyoxalase pathway

  2022-07-06

  

  The presence of an active glyoxalase pathway in an apicomplexan parasite was first reported in Plasmodium falciparum-infected erythrocytes (Vander Jagt et al., 1990). Some years later, glyoxalase I and both glyoxalase II enzymes were characterized in this parasite (Akoachere et al., 2005, Iozef et

• Xie et al b reported

  2022-07-06

  

  Xie et al. (2009b) reported that the combination of diagnostic ultrasound impulses and cyclic RGD-bearing MBs targeted for GP IIb/IIIa resulted in the successful recovery of epicardial and microvascular blood flow in swine models with acute thrombotic occlusion. It is well known that the stability o

• Although the ramifications of non

  2022-07-06

  

  Although the ramifications of non-additive SAR are context-dependent, the knowledge that perturbations in one region of a chemical series are not synergistic with perturbations in another region of the same chemical series is clearly pertinent to any medicinal chemistry effort. In our experience, no

• br Voltage dependent anion channel VDAC is

  2022-07-06

  

  Voltage-dependent anion channel VDAC is a ubiquitous protein showing well conserved structural and functional properties in spite of major variations in its sequence (for review see [50]). Most of what we know about VDAC electrophysiological properties (for reviews, see [51], [52]) was initially

• br Results and discussion br Conclusion In

  2022-07-05

  

  Results and discussion Conclusion In the continued SAR study of our previous heterocycle scaffolds represented by plicamycin 2, we focused especially on improving their drug-like physicochemical properties directed by lipophilicity, LE and LLE. After explored several heterocyclic scaffolds, t

• br Short Communication Free fatty acid receptors FFAR play s

  2022-07-05

  

  Short Communication Free fatty SB742457 synthesis receptors (FFAR) play significant roles in energy metabolism (Brown et al., 2005; Ichimura et al., 2009). The receptor FFAR1 is involved in insulin secretion in humans (Meidute Abaraviciene et al., 2013). Activation of the receptor FFAR2 increases

• 391 sale Studies have indicated that formylated peptides FPR

  2022-07-05

  

  Studies have indicated that formylated peptides, FPRs, and in particular FPR-1 may be principal conductors in inflammatory processes in sterile-24, 26 and infection-related diseases. FPR-1 and formylated peptides, which are active components of CS, have been involved in smoking-induced lung damage,

• The Jumonji JmjC domain containing KDM

  2022-07-05

  

  The Jumonji (JmjC) domain-containing KDM family members can be clustered into seven subfamilies (KDM2 – KDM8). The KDM2 cluster catalyzes H3K36me2/me1 demethylation; in addition, KDM2B/JHDM1B/FBXL10 has been suggested to catalyze demethylation of H3K4me3 [3]. Cell culture studies support that KDM2 p

15208 records 390/1014 page Previous Next First page 上5页 386387388389390 下5页 Last page