• We also intended to determine the

  2022-08-24

  

  We also intended to determine the possible mechanism underlying EZH2 upregulation in the PC. Although no recurrent mutations of EZH2 have been described in CLL [27, 28, 29], we aimed to rule out the possibility of activating mutations in the background of EZH2 overexpression. We detected no mutation

• br Experimental br Results br Discussion In this study

  2022-08-24

  

  Experimental Results Discussion In this study, we performed molecular docking analysis and in vitro studies to determine whether genistein binds to HIF-1α in BC Nile Red and identify the residues involved in this interaction. We found that some functional groups (residues) mimic the bindin

• One of the key epithelium derived

  2022-08-24

  

  One of the key epithelium-derived factors required to maintain immune tolerance in the intestine is Indian Hedgehog (Ihh). Ihh is secreted exclusively by intestinal epithelial cells, and signals in a paracrine manner to the inhibitory receptor Patched1 (Ptch1) on rb 1 synthesis in the mesenchyme.

• HBV VL quantitation has been shown to be affected by

  2022-08-24

  

  HBV VL quantitation has been shown to be affected by genotype/subtype, and varying degrees of positive and negative bias has been seen in previous comparison studies when analyzing across HBV genotypes. In studies comparing RealTime and Cobas for example, negative bias of ∼0.25 log10 was seen for ge

• miRNAs post transcriptionally regulate gene expression by

  2022-08-24

  

  miRNAs post-transcriptionally regulate gene Dynorphin A by cleaving mRNA or inhibiting translation of target gene transcripts. Vita analysis of HBV genome sequence suggested that miR-185-5p may not directly act on HBV mRNAs, which suggested that miR-185-5p might suppress HBV gene expression and repl

• br S Nitrosoglutathione reductase GSNOR also

  2022-08-24

  

  S-Nitrosoglutathione reductase (GSNOR) also identified as glutathione-dependent formaldehyde dehydrogenase (FDH), is a zinc-dependent dehydrogenase. It is a member of the alcohol dehydrogenase (ADH) family and is called class III alcohol dehydrogenase that regulates the levels of S-nitrosothiols (

• br Mechanism of action of herbs and their active constituent

  2022-08-24

  

  Mechanism of action of herbs and their active constituents used in hair loss treatment The hair growth cycle consists of 4 stages known as the anagen (active growth phase; takes 2–7years), catagen (involuting or regressing phase; takes approx. 2weeks), telogen (short resting phase; takes approx.

• br Materials and methods br

  2022-08-24

  

  Materials and methods Results and discussion Conflict of interest Introduction In the presence of continuous and excessive levels of nutrients, adipocytes become hypertrophic and release several pro-inflammatory adipocytokines such as interleukin-6 (IL-6), monocyte chemoattractant protei

• Glycogen synthase kinase GSK is currently considered to be a

  2022-08-24

  

  Glycogen synthase kinase 3 (GSK3) is currently considered to be a multifunctional serine/threonine kinase involved in a wide spectrum of cellular processes such as glycogen metabolism, cell proliferation, neuronal function, oncogenesis or embryonic development (for recent reviews see: Rayasam et al.

• This resembles a vicious cycle since BBB disruption and infl

  2022-08-24

  

  This resembles a vicious cycle since BBB disruption and inflammation are thought to be caused by epilepsy, but other contributing factors are also known to be their cause, such as peripheral infection, autoimmunity, ciprofloxacin trauma and stroke that also underlie epilepsy [18]. Additional trigge

• br Acknowledgments br Free fatty acids FFAs are

  2022-08-24

  

  Acknowledgments Free fatty acids (FFAs) are not only essential nutritional components, but they also function as signaling molecules. Recently, a G protein-coupled receptor (GPCR) de-orphanizing strategy successfully identified multiple receptors for FFAs, which function on the cell surface and

• We confirmed a decrease in extracellular glutamate uptake

  2022-08-24

  

  We confirmed a decrease in extracellular glutamate uptake and the presence of efflux in an endothelial cell model of oxygen-glucose deprivation (OGD), which effectively simulates the inefficient energy supply after brain injury [15], and analysed the function of endothelial EAATs and explored the ro

• One may carefully evaluate the concept

  2022-08-23

  

  One may carefully evaluate the concept ‘pancreas derived GLP-1′ as this may dependent on the specificity of the CEP-18770 used in immunohistochemistry or radiommunoassays. If either a side-viewing antibody or a C-terminal wrapping antibody raised against GLP-1 is applied one may also identify N-ter

• ciprofloxacin Both preclinical and clinical studies

  2022-08-23

  

  Both preclinical and clinical studies have identified a distributed set of CNS nuclei that participate in cognitive control of feeding behavior. Preclinical studies that utilize restricted access feeding schedules (RFS) indicate that rodents learn to anticipate delivery of scheduled meals as indicat

• By using pharmacological treatment with CBX or transgenic an

  2022-08-23

  

  By using pharmacological treatment with CBX or transgenic animals lacking the two major astroglial Cxs, the Double KO mouse, we demonstrated that the gap-FRAP technique was able to detect the total inhibition of GJC with a reduction of about 39% and 38% compared to control, respectively. The residua

15263 records 369/1018 page Previous Next First page 上5页 366367368369370 下5页 Last page