• Autophagy is a self protecting cellular catabolic pathway th

  2023-11-21

  

  Autophagy is a self-protecting cellular catabolic pathway that degrades and recycles cytoplasmic contents for the maintenance of cellular homeostasis (Shao et al., 2016b). Macrophage autophagy plays an essential role in atherosclerosis by safeguarding PF-2341066 against oxidative stress, reducing a

• br Material and methods br Results br Discussion Didox

  2023-11-21

  

  Material and methods Results Discussion Didox was originally created asa cytostatic drug to inhibit cancer cell proliferation by antagonizing RNR [11]. When used to target highly proliferative cells, Didox has extensive activity in vitro and in vivo. It has also been employed in clinical st

• Since artemisinin shows low solubility and poor oral

  2023-11-21

  

  Since artemisinin shows low solubility and poor oral bioavailability [8], [9], derivatizations of artemisinin were carried out and yielded different semisynthetic antimalarial drugs such as artemether and sodium artesunate. Artemether (decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano [4.3-

• Hydroxysafflor yellow A br Removal of therapeutic doses of

  2023-11-21

  

  Removal of therapeutic doses of Hydroxysafflor yellow A from Marek’s Disease Vaccines The impact of this change seems to vary widely among operations, probably dependent on the pre-existing quality of hatching egg production, hatchery sanitation, hatchery management, and brooding management. Inc

• br Acknowledgements br Introduction The

  2023-11-21

  

  Acknowledgements Introduction The angiogenic ocular conditions represent the most common cause of blindness in developed countries [1]. It can affect all ages, for example, retinopathy of prematurity (ROP) in infants [2], [3], diabetic retinopathy (DR) [4] in working age adults and age-related

• br Prostate cancer and resistance

  2023-11-21

  

  Prostate cancer and resistance to AR targeting treatment The AR plays a pivotal role in the development, differentiation, homeostasis and secretory function of the normal prostate (Wilson, 2011). The AR is also a key player in many phases of prostate carcinogenesis (Huggins et al., 1941, Scher an

• Thus far a tight coupling has been

  2023-11-21

  

  Thus far, a tight coupling has been observed between mAbs that target aggregated Aβ and the occurrence of ARIA. If ARIA-E is caused by increased trafficking to and clearance of fibrillar Aβ from cerebral vessels (20), mAbs could be designed with conformationally specific epitopes selective for solub

• peptide yy To date LOX is the only LOX isoform that has

  2023-11-20

  

  To date, 12-LOX is the only LOX isoform that has been identified in the platelet [17]. Interestingly, while 12-LOX is highly expressed (∼14000 molecules/platelet) in the platelet, 12(R)-LOX expression is absent in the hematopoietic lineage and has therefore not been reported to be expressed in plate

• casein kinase 2 The cavity volume of the binding

  2023-11-20

  

  The cavity volume of the binding pocket may differ not only between species but also among various AhR/ARNT isoforms within a single species. It is noteworthy that even a single amino casein kinase 2 substitution within a binding pocket may result in a change in the cavity volume. This, in turn, may

• Pyrintegrin br Actin cytoskeleton in protrusion Pushing forc

  2023-11-20

  

  Actin cytoskeleton in protrusion Pushing force driving membrane protrusion is generated by polymerizing Pyrintegrin filaments organized either into branched networks or parallel bundles. Branched networks are assembled through Arp2/3 complex-dependent actin nucleation and drive protrusion of lam

• The presence of different LO splice variants was first demon

  2023-11-20

  

  The presence of different 5-LO splice variants was first demonstrated in human A 77636 hydrochloride sale tumour cells and in dimethyl sulfoxide-differentiated HL-60 cells [40] and a correlation between the 5-LO splicing pattern and the malignancy of the brain tumours was found. Later, other splice

• Introduction Mitotic kinases play an essential role in mitos

  2023-11-20

  

  Introduction Mitotic kinases play an essential role in mitosis, Aurora and other mitotic kinases are often observed over-expression in human solid and many hematologic cancers. As one of serine/threonine kinases, Aurora kinase family is involved in centrosome maturation, mitotic spindle formation,

• In addition to pH regulation by ion counter fluxes

  2023-11-20

  

  In addition to pH regulation by ion (counter-) fluxes, acidification is regulated by the abundance of V-ATPase on organelles, by the pumping activity of the complex and by proton leakage. In yeast, the V-ATPase VO subunit a is the only subunit expressed in two isoforms termed Stv1p and Vph1p. V-ATPa

• Complementing the effects of ARB

  2023-11-20

  

  Complementing the effects of ARB and ACEI on HDL capacity to elicit cholesterol efflux, HDL of ARB- and ACEI-treated groups significantly lessened macrophage production of superoxide (Fig 2). As with efflux, there was no difference in this effect between the ARB and ACEI groups. These data are inter

• Ultracentrifugation of AD brain was reported to remove of

  2023-11-20

  

  Ultracentrifugation of AD DPQ was reported to remove >99.95% of Aβ, while only reducing seeding capacity by 70% (Langer et al., 2011). This suggests that the most potent seeding Aβ species are relatively small soluble oligomers rather than larger insoluble fibrils. It was also noted that this potent

15208 records 229/1014 page Previous Next First page 上5页 226227228229230 下5页 Last page